Cast members from Twighlight and Gossip Girl as well as Corbin Bleu, Hayden Panettiere (pictured) and a host of stars appear in a new One PSA.
The team say, ‘We can defeat extreme poverty and preventable disease by all working together.’
News of the PSA for the Come Together as One Campaign comes as the world marks another World AIDS Day, 1 December.
You can see the One PSA online, or watch the television debut on Wednesday night’s episode of Gossip Girl.